Is it possible to nest VPN connections?

Is it possible to create an VPN connection while using site-to-site VPN?

Have you ever tried or done this?

What are possible problems, pitfalls, things of the impossible, etc. ?

Also see: http://serverfault.com/questions/126537/is-it-possible-to-use-microsofts-secure-connection-rules-ipsec-with-vpn

From serverfault Tie-fighter

• You're likely to start having issues related to MTU, but yes, it can work.

  Whether it will work depends on what exact combination you're hoping to achieve.

  From LapTop006